Reappearance of neutrophils in intestinal mucosa from IBD patients with clinical remission has also been considered as a hallmark of disease relapse, and the decrease and absence of mucosal neutrophils is a goal of histological healing.39 To illustrate the influence of butyrate on the migration of neutrophils, we utilized a Transwell model and identified that butyrate could inhibit IL-8-induced neutrophil transmigration. The gene discussed is CXCL8; the disease is inflammatory bowel disease.