A recent report provided confirmation of 15-LOX-1/13(S)-HODE mechanisms using conditional knockout and over-expressing mouse models of colorectal cancer, which implicated LRP5-SNX17 interactions.27 Future experiments will seek to corroborate additional mechanistic leads from the work reported here, including the dietary fiber aspects and other targets identified by integrated multi-omics. The gene discussed is SNX17; the disease is colorectal cancer.