Metabolites downstream of linoleate and 15-lipoxygenase-1 (15-LOX-1), such as (13S)-hydroxyoctadecadienoic acid (13(S)-HODE), exert proapoptotic antitumor mechanisms in CRC.25–27 Notably, lower levels of these metabolites in Pirc colon tumors tended to be normalized in adenomatous polyps following SPI treatment, comparable to the levels detected in normal-looking Pirc colon ±SPI (Figure 7a). The gene discussed is ALOX15; the disease is colorectal carcinoma.