NRF1 and hydrops fetalis: For example, single-cardiomyocyte transcriptomics demonstrated that transition from compensated hypertrophy into HF primarily involves activation of extracellular-signal-regulated protein kinases 1 and 2 (ERK1/2), nuclear respiratory factors 1 and 2 (NRF1/2) and p53 signaling (Nomura et al., 2018).