In agreement, an upregulation of MMP-9 has been associated with pathological remodeling of the cardiac ECM (Sung et al., 2018, 2020; Tao et al., 2004), contributing not only to exacerbate matrix turnover, but also for inflammation following MI (Deleon-Pennell et al., 2016). This evidence concerns the gene MMP9 and myocardial infarction.