FN1 and type 2 diabetes mellitus: Fibronectin (Fn1) has been particularly linked to the accumulation of ECM proteins, and treatment with the SGLT2 inhibitor canagliflozin in individuals with type 2 diabetes and elevated urine ACR has been shown to downregulate plasma levels of fibronectin, thereby reducing the fibrosis biomarker (Heerspink et al., 2019).