Consistent with marked glomerulosclerosis in UNx-Renin mice, ECM-associated gene expression changes were more pronounced in UNx-Renin mice, in which additional markers of fibrogenesis were significantly upregulated, including Col1a1, Col3a1, Col6a1, Col6a2 and Mmp7. The gene discussed is COL6A1; the disease is glomerulosclerosis.