In addition to the previously mentioned in vitro data, we report here for the first time to our knowledge the PD-relevant, increased accumulation of H3K27ac in an ex vivo model (rotenone-exposed midbrain slice cultures), in the in vivo MP mouse model (a TFAM conditional KO PD), and in the postmortem human SN. The gene discussed is TFAM; the disease is Parkinson disease.