XDH and metabolic dysfunction-associated steatohepatitis: Supporting the clinical evidence mentioned above, NASH mice fed CDAHFD exhibited significantly augmented neointimal proliferation induced by carotid artery ligation (P < 0.001).Topiroxostat is reported to inhibit plasma XOR activity more effectively than other XOR inhibitors, allopurinol and febuxostat, in both mice (39) and humans (40).