In line with our in vitro phenotypes (Figure 4B), we also confirmed that shHDAC1 tumors expressed very low levels of OLIG2 — a master transcription regulator that has previously been shown to be critical for the tumor-propagating potential of p53-WT GSCs (Supplemental Figure 5C and refs. 36, 40). The gene discussed is OLIG2; the disease is neoplasm.