Our transcriptional regulatory network analysis (Figure 6D) revealed that HDAC1 silencing in p53-WT hGSCs resulted in the upregulation of multiple transcription factors that are associated with several hallmarks of cancer (e.g., tumor-promoting inflammation, evasion of apoptosis, tissue invasion, and metastasis), which promote tumor growth and survival. This evidence concerns the gene TP53 and neoplasm.