RTN4R and neoplasm: synthesized a new kind of Bio‐MVs‐based “guided shells” for OA camouflaging and delivery.[52] Herein, the NGR tripeptide (Asn‐Gly‐Arg) as the targeting ligand was selected for Bio‐MVs modification because the NGR could recognize a membrane‐bound metalloproteinase (APN) of tumor cells.[53] (Figure 1) First, the NGR coded cDNA was knocked in the Gypa, one marker of RBCs, through in vivo CRISPR‐engineering strategy.