SHOX2 and breast cancer: Studies have also shown that miR-375 can reduce the protein expression of Short SHOX2 and inhibit the proliferation of human BC cells, many BC cell lines have shown that SHOX2 acts as an inducer of EMT and also acts as a TGF-β receptor I (TβR-1) transcription factor that affects EMT through the TGF-β signaling pathway [38].