SP1 and colorectal carcinoma: SP1 is known to be a downstream target of miR-375, so, miR-375 targets SP1 to inhibit EMT-related genes, such as matrix metalloproteinase 2 (MMP2), vimentin, snail, β-catenin, N-cadherin, thereby inhibiting the migration and invasion of human CRC cells (DLD1, HCT8) [19].