STAT3 and cancer: Several pathways representing cancer hallmarks, such as interferon-alpha (IFN-α) response, myc targets, unfolded protein response, transforming growth factor (TGF)-β signaling, cholesterol homeostasis, and interleukin 6 (IL6)-Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signaling, were upregulated in the glycolysis-high group.