At 48 hpi SK-N-SH cells infected with all four isolates [G, C (HFMD, C (Enc) and D] secreted higher amount IL-6, IL-8, IP-10 and TNF-α but the G genotypes infected cells continued to evoke higher responses than others particularly for production of TNF-α IFN-γ and IP-10 (p < 0.001) (Fig. 4C). This evidence concerns the gene CXCL10 and hand, foot and mouth disease.