Representative images of an LGR5-positive BC showing high levels of EGFR, CK5/6, and Ki-67, as well as a complete loss of P53, are presented in Fig. 4A. We measured the EGFR H-scores and CK5/6 expression, as well as the percentages of Ki-67- and P53-positive cancer cells in 18 LGR5-expressing BCs. This evidence concerns the gene TP53 and breast cancer.