With WGCNA, we found that genes in the blue, turquoise and brown modules occupied the dominance of all the DEG sets, indicating that these genes, such as SELENBP1, SLC4A1, HSPA8P4, CALM1 and CAPN2, CXCR1, and CXCR2, played a marked role in the generation, development and molecular regulation of HCC. This evidence concerns the gene CXCR2 and hepatocellular carcinoma.