Several DEGs selected (SELENBP1, SLC4A1, SLC26A8, HSPA8P4, CALM1 and RPL7p24) were confirmed by qRT-PCR, and to our knowledge, SLC4A1, RPL7p24, CALM1 and SLC26A8 were first found to be related to HCC, suggesting that potential biomarkers could be analyzed for the classification, stages and therapeutic target of HCC in future studies. This evidence concerns the gene HSPA8P4 and hepatocellular carcinoma.