Since we found a strong association between ERG and DLX1 expression in several independent PCa cohorts, we next sought to investigate the role of ERG in transcriptional regulation of DLX1. Thus, we analyzed publicly available ERG ChIP-Seq dataset in VCaP (TMPRSS2-ERG fusion-positive) cells40,41, and an increased enrichment of ERG on the DLX1 promoter was observed, while it was reduced in ERG depleted cells (Fig. 5a). This evidence concerns the gene TMPRSS2 and posterior cortical atrophy.