DLX1 and posterior cortical atrophy: To further explore the oncogenic role of DLX1 in aggressive PCa, we analyzed RNA-Seq data (GSE78913)23 for the transient knockdown of DLX1 in LNCaP derivative osteotropic cell line C4-2B, and as speculated DLX1 was found to be one of the top five downregulated genes as depicted in the volcano plot (Supplementary Fig. 1h).