RNAscope in situ hybridizations in a MYCN-amplified neuroblastoma case (K10, Supplementary Data 1) as independently confirmed by comparative genomic hybridization (CGH)20, revealed a high intratumoral heterogeneity for TH, MYCN, and ALK expression, with tumor regions with intense staining of MYCN and ALK, negative for TH (Fig. 4a, zoom 2). Here, ALK is linked to neuroblastoma.