Significant expression of (nor-)adrenergic (“NOR”) markers (i.e., CHGA, CHGB, DBH, TH, PHOX2A, and PHOX2B) is common for healthy sympatho-adrenal cells and tumor NOR populations identified in low-risk neuroblastoma cases (FDR < 0.01, Welch’s t-test, Fig. 5a, Supplementary Data 2). The gene discussed is TH; the disease is neuroblastoma.