Our research for the diagnosis and prognosis of osteosarcoma provides a potential therapeutic target, but the generation of osteosarcoma has a variety of reasons, the onset process also involves many factors, and our research still not perfect, such as how SRGN affects JAK/STAT signal pathway, and its possible mechanism of SRGN is unclear and so on, all this needs further research. This evidence concerns the gene SRGN and osteosarcoma.