In addition, network analysis identified key hub genes (CLCNKB, KDSR, KIAA0586, OCRL, FANCM, TGDS, NDN) that make an inter-connection between most of the identified human phenotypes, suggesting their prominent role in the progression of LMM and a cross talk between immune-inflammation and muscle mass decline. This evidence concerns the gene KIAA0586 and lentigo maligna melanoma.