Although a tau-centric hypothesis ascribing a primary role to tau40 has been proposed as an alternative to the view that AD is caused by the accumulation of Aβ in the brain,41 both spline- and correlation-based sensitivity analyses in CU individuals by Aβ status showed there to be little association with Aβ and tau-PET in Aβ-negative CU individuals. The gene discussed is MAPT; the disease is Alzheimer disease.