Thus far, however, there are no studies comparing p-tau181, p-tau217, and p-tau231 levels in relation to Aβ and tau-PET across the symptomatic stages of AD, nor data directly comparing their diagnostic performance for separating AD dementia from non-AD neurodegenerative disorders and for identifying abnormal Aβ and tau-PET status. This evidence concerns the gene MAPT and Alzheimer disease.