ATP13A3 and idiopathic pulmonary arterial hypertension: Recent sequencing studies have accelerated the identification of additional risk genes,3–5 including monoallelic ATP13A3 variants associated with adult-onset IPAH across genetic ancestries.3 4 6 7ATP13A3 encodes a P-type ATPase, a cation transporter with a documented role in the polyamine transport system.8