Furthermore, several genes belonging to the Ras GTPase-activating protein (RasGAP) family, including RASA3 (P = 0.0005), RASA4 (P = 0.003), and RASAL3 (P = 0.0016), were identified with hypermethylated promotors in EBVaGCs compared with that in precursor lesions and other gastric cancers (Fig. 6i, Additional file 1: Figures S8b and S9). This evidence concerns the gene RASA4 and gastric cancer.