ALKBH1 and cancer: Different from other studies showing dysregulation of ALKBH1 activity causes many human diseases, including cancer [45], our findings indicate that the precise regulation of ALKBH1 expression is also important and abnormal ALKBH1 expression is associated with deficiency of human trophoblast cells functions such as EMT, which is consistent with a previous report showing Alkbh1 knockout mice (Alkbh1−/−) resulted in impaired placental trophoblast lineage differentiation [46], suggesting the essential role of ALKBH1 in placentation and embryonic development.