Despite a previous report showing that RGS2 down-regulation was observed in early prostate cancer (PC) caused by hypoxia and E-cadherin expression was decreased [22], which suggests priming for EMT and is inconsistent with our findings here, high RGS2 levels were correlated to poor patient survival and a positive metastatic status in advanced PC, indicating the different roles of RGS2 between indolent and metastatic forms of cancer and further suggesting that RGS2-related EMT during embryogenesis and carcinogenesis may share different molecular mechanisms. Here, RGS2 is linked to prostate cancer.