We determined that HCT15 and SW620 cells have no or vestigial expression of NMURs, HCT116 cells express NMUR1, and Caco-2, HT29 and SW480 cells express NMUR2. NMU is able to activate signalling pathways in CRC cells expressing NMU receptor. This evidence concerns the gene NMUR1 and colorectal carcinoma.