SA-49 treatment facilitates PKCα/GSK3β/MITF-mediated PD-L1 autophagic degradation [36], and DHHC3 inhibitor 2-bromopalmitate (2-BP) abolishes PD-L1 palmitoylation resulting in PD-L1 autophagic degradation [34], subsequently, enhances the efficacy of cancer immunotherapy in a colon tumor model. Here, CD274 is linked to colonic neoplasm.