FUNDC1 and hepatocellular carcinoma: As a mitophagy receptor, FUN14 domain-containing 1 (FUNDC1)-mediated mitophagy inhibits hepatocellular carcinoma (HCC) initiation and progression in response to diethylnitrosamine, whereas hepatocyte-specific FUNDC1 deficiency increases dysfunctional mitochondria accumulation and cytosolic mitochondrial DNA (mtDNA) release, which in turn promotes proliferation of hepatocytes by pro-inflammatory response [52].