CA9 and squamous cell carcinoma: In summary, we report the squamous cell carcinoma highly associated genomic locus Chr3q29 can generate a pair of alternative promoter-regulated lncRNA variants 887S and 887L. The two lncRNAs are differentially responded to hypoxia and oppositely control tumorigenesis through distinct but interplaying transcriptional regulatory axis on oncogene CA9. This integrated and coordinated collaboration between 887S and 887L results in a fine controlled expression level of CA9.