DUOXA2 and autism spectrum disorder: In the research of Siwei Chen et al., the De novo missense variants in Autism Spectrum Disorder (ASD) patients could impact the risk of ASD by destroying interaction of protein–protein, which is a universal phenomenon in various diseases [33, 34].Dual-oxidase maturation factor 2 (DUOXA2) is a component of thyroid hydrogen peroxidase (H2O2) generator, which is essential to hormone synthesis.