Immuno-histochemical analysis showed that all the three patients (P7–P9) had similar levels of SPAG9 expression in their tumor (80–90%) with 2 + intensity (Table 1), leading us to speculate that tumor lysates could have a varying mixture of tumor associated antigens with differing antigenicity leading to variation in response levels compared to the single protein antigen rhSPAG9. Here, SPAG9 is linked to neoplasm.