These results indicated that the mRNA expression of COMMD1/2/3/4/7/8/9 was markedly associated with prognosis in liver cancer patients and that the mRNA expression levels of COMMD3/4/5/7/8/9/10 were significantly related to prognosis in patients with grade 3 HCC. This evidence concerns the gene COMMD1 and hepatocellular carcinoma.