In 124 patients with grade 3 HCC (clinical characteristics are listed in Supplementary Table 2), univariate analysis showed that high mRNA expression of COMMD3 (HR = 2.82, 95% CI: 1.40–5.70, and p = 0.004) was related to shorter OS (Table 3). This evidence concerns the gene COMMD3 and hepatocellular carcinoma.