Multivariate analysis revealed that only high mRNA expression of COMMD3 (HR = 2.16, 95% CI: 1.33–3.48, and p = 0.002) was independently associated with significantly shorter OS among all HCC patients (Table 2) indicating that COMMD3 is an independent prognostic factor for OS in all HCC patients. The gene discussed is COMMD3; the disease is hepatocellular carcinoma.