Compared with patients without MBE, those with MBE had higher levels of serum concentration of NLRP3 on admission (median concentration 1.85 [IQR 0.98–3.87] ng/ml vs. 1.11 [0.94–2.44] ng/ml, P = 0.026; median time from the onset of stroke to blood sample collection 3 h, IQR 2-4 h). Here, NLRP3 is linked to stroke disorder.