In previous reports, MSCs have shown anti-renal fibrosis effects through secretion of various growth factors and cytokines such as epithelial growth factor (EGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factors-1 (IGF-1) and transforming growth factor-beta (TGFβ) [29,30]. Here, IGF1 is linked to renal fibrosis.