Further studies using RNA sequencing and/or chromatin immunoprecipitation along with gene expression profile may respectively help describe more precisely t(4;12) breakpoints and provide a better understanding of the CHIC2 or PDGFRA/ETV6 fusion protein and/or GSX2 role in t(4;12) myeloid malignancies. Here, PDGFRA is linked to myeloid neoplasm.