Another type of dementia, frontotemporal dementia (FTD) (Also known as Pick’s disease after Arnold Pick, who first noticed a patient with distinct symptoms affecting language in 1892), is also related to the tau and TDP-43 proteins; however, LATE usually can be distinguished from FTD, because FTD typically affects people under age 60 while LATE affects older people, and LATE neuropathologic change has a relatively restricted neuroanatomical distribution of TDP-43 proteinopathy [3]. Here, TARDBP is linked to Pick disease.