Here we employed three existing clinical or neuropathological diagnostic criteria to categorize whether a subject has AD and/or LATE: 1) Braak score [8, 9], which is an ordinal measure to delineate the distribution and severity of NFT pathology with seven stages 0–6; 2) CERAD score [9, 10], which is a semiquantitative measure with four grades 1–4 to describe the neuritic plaque density; 3) TDP-43 stage [11], which has four grades to measure the TDP-43 distribution, or, a recommended dichotomy version with values 0 and 1 by the Rush AD Center (RADC). The gene discussed is TARDBP; the disease is Alzheimer disease.