A similar study by Zheng et al. found stroke-prone renovascular hypertensive rats (RHRSPs) treated with rosuvastatin (10 mg/kg/day; 12 weeks) had higher levels of zonula occludens-1, claudin-5 and occludin proteins in the corpus callosum compared to untreated rats [23]. The gene discussed is CLDN5; the disease is Stroke.