HSD17B12 and type 2 diabetes mellitus: Further, other 18 variants mapped to HSD17B12 are associated with diseases including Type-2 diabetes, cardiovascular disease, and coronary artery diseases in the GWAS Catalog, suggesting a role for HSD17B12 in the modulation of healthspan that is in line with our observation that depletion of let-767 improves healthspan in C. elegans.