In addition to R173H acting nearly functionally normally in two yeast assays (S6 and S7 Figs), it also acted normally in a premalignant mammary epithelial cells lacking PTEN (MCF10A cells) [77], and recapitulated a PTEN-WT gene expression signature for 978 landmark genes in HA1E cells, and failed to contribute to tumor formation in a mouse model [50, 77, 78]. Here, PTEN is linked to neoplasm.