This mechanism of CSD initiation may be implicated in other types of migraine and possibly in other pathologies in which SDs are involved (e.g., stroke, traumatic brain injury, and subarachnoid hemorrhage; ref. 1), because it could be associated not only to NaV1.1 mutations, but also to other dysfunctions that lead to GABAergic neuron hyperactivity. Here, SCN1A is linked to stroke disorder.