In summary, our study reveals a previously unrecognized role of PLA2G2F, an epidermal sPLA2, and PLA2G4D and PLA2G4E, epidermal cPLA2s, in skin homeostasis and inflammation, and through our in vitro and in vivo models demonstrates and highlights the potential promise of targeting PLA2s in psoriasis and PRP. The gene discussed is PLA2G2A; the disease is psoriasis.