AXL and acute myeloid leukemia: In addition, ALKBH5 is known to post-transcriptionally regulate TACC3 to promote tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia (AML) [45], whereas the KDM4C-ALKBH5-AXL signaling axis participates in chromatin alterations in AML leukemia stem cells [50].