For example, ALKBH5 functions as a tumor suppressor in ESCC (this study), hepatocellular carcinoma [40], pancreatic cancer [43, 46], and lung cancer [44], whereas it exerts pro-tumorigenic effects on leukemia [45, 50], glioblastoma [51], and breast cancer [52]. This evidence concerns the gene ALKBH5 and esophageal squamous cell carcinoma.