The lack of CUL3 has been associated with defects in embryogenesis, hypertension, diminished angiogenesis, progressive interstitial inflammation, exacerbated colonic inflammation, and swelled spleens and lymph nodes (Agbor et al., 2019; Li et al., 2017; Maekawa et al., 2017; Mathew et al., 2012; Saritas et al., 2019; Singer et al., 1999). This evidence concerns the gene CUL3 and hypertensive disorder.