Upon the adoptive transfer of these cells along with WT-mice-derived naive CD4+ T cells used to induce colitis into Rag1-/- recipient mice (Figure 6A), Th0 (WT) group suffered serious colitis lying in body weight loss, disease activity index (DAI) score increase, colon length shortening, inflammatory cell infiltration, mucosal edema and injury as well as crypt damage increase (Figure 6C–E). This evidence concerns the gene RAG1 and colitis.