SEPSECS and autoimmune hepatitis: Of interest, anti-SLA is seen in both AIH-1 and AIH-2, a feature that, coupled with its high disease specificity, suggests a key pathophysiological role of its antigenic target, i.e. the intracellular enzyme O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS), required for selenoprotein biosynthesis, originally identified by Gelpí in 1992, and later confirmed by Wies and by Volkmann as the molecular target of anti-SLA [85–88].