TMSB10 and tuberculosis: 12 genes were identified in the reduced signature that were shared between the top 30 genes distinguishing active TB from LTBI, and active TB from ODs, ranked by decreasing importance (mean decrease accuracy; Fig. 8, A and B), further reduced to 10 genes (TB10) based on performance (area under the curve [AUC] and accuracy) on pooled cohort datasets with independent validation (Fig. S5 C and Table S5).