IFNA1 and tuberculosis: At 0–31 d before diagnosis, the modular signature for the Zak progressors (Fig. 4 F) was almost identical to that of active TB (Fig. 4 D, far right; Moreira-Teixeira et al., 2020; Singhania et al., 2018a), although with less enrichment as at a nominal P value of 0.05 (Fig. 4 F), including enrichment of inflammasome/granulocytes, innate/hemopoetic mediators, innate immunity PRR/C’/granulocytes, IFN/PRR, and IFN/C’/myeloid modules and decreased enrichment of T cell, B cell, and NK and T cell modules.