More importantly, knockdown of KIF20A significantly decreased the IC50 values of sorafenib in both HepG2 (Figure 8E, 8F) and SK-Hep1 cells (Figure 8G, 8H) when compared to si-NC group, suggesting the KIF20A increased the chemo-sensitivity to sorafenib in HCC cell lines. The gene discussed is KIF20A; the disease is hepatocellular carcinoma.