Based on the above results, 12 hub genes (AURKA, CCNA2, CDC20, FOXM1, HMMR, KIF20A, OIP5, PRC1, PTTG1, TOP2A, TPX2 and TRIP13) predicting both poor overall survival and DFS of patients with HCC were further confirmed using UALCAN databases. The gene discussed is AURKA; the disease is hepatocellular carcinoma.