In conclusion, this study identified 177 common DEGs among 5 GEO microarray datasets, and found that 10 hub genes (AURKA, CCNA2, CDC20, FOXM1, HMMR, KIF20A, PTTG1, TOP2A, TPX2 and TRIP13) could predict the poor prognosis of HCC patients using comprehensive bioinformatics analysis. This evidence concerns the gene HMMR and hepatocellular carcinoma.