As shown in Figure 7F and 7G, KIF20A knockdown significantly increased the caspase-3 activities in both HepG2 and SK-Hep1 cells (Figure 7F, 7G); and consistent findings for caspase-9 were also detected in the HCC cells with KIF20A siRNA transfection (Figure 7H, 7I). Here, CASP3 is linked to hepatocellular carcinoma.