In conclusion, this study identified 177 common DEGs among 5 GEO microarray datasets, and found that 10 hub genes (AURKA, CCNA2, CDC20, FOXM1, HMMR, KIF20A, PTTG1, TOP2A, TPX2 and TRIP13) could predict the poor prognosis of HCC patients using comprehensive bioinformatics analysis. Here, TOP2A is linked to hepatocellular carcinoma.