In other models, the recruitment of TDP-43 in stress granules rather plays a negative role in neurodegenerative diseases by acting as crucibles in which TDP-43 is concentrated (Li et al., 2013; Zhang et al., 2015; Langdon and Qiu, 2018; Van Treeck et al., 2018; Dobra et al., 2018; François-Moutal et al., 2019). The gene discussed is TARDBP; the disease is neurodegenerative disease.