TARDBP and amyotrophic lateral sclerosis: Since TAR DNA-binding protein 43 (TDP-43), a nuclear mRNA-binding protein with a self-attracting LCD (Cao et al., 2019; Tollervey et al., 2011), was associated to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) pathologies (Neumann et al., 2006; Arai et al., 2006; Sreedharan et al., 2008; Vogler et al., 2018; Chou et al., 2018), the notion that deregulated RBP assemblies may be responsible for RBP aggregation has made its way (Li et al., 2013; Patel et al., 2015).