Alzheimer’s disease (AD), the leading cause of dementia globally (Livingston et al., 2017), is characterised by synaptic dysfunction and neurodegeneration (e.g., neuronal loss), triggered by sequential accumulation of amyloid plaques and neurofibrillary tangles (aggregates of hyperphosphorylated tau proteins) (Braak and Braak, 1991). Here, MAPT is linked to Alzheimer disease.