CXCL8 and congestive heart failure: Our study revealed that the plasma levels of IL-1β, IL-6, IL-8, and TNF-α in patients taking ACEI/ARBs were lower than those in patients not without medication; in addition, persistently lower levels of proinflammatory factors were maintained in patients who continued medication during hospitalization, which was consistent with the previous experimental results by Gullestad et al. (25) with the conclusion that high-dose enalapril was associated with a significant decrease in IL-6 activity in patients with severe chronic heart failure.