Moreover, CDK7 expression is positively correlated with that of the estrogen receptor (ER) and plays a role in phosphorylating Ser118 on the ER, which promotes ER activity, and CDK7 blockade contributes to reverse endocrine therapy resistance in breast cancer (Patel et al., 2016; Attia et al., 2020). The gene discussed is ESR1; the disease is breast cancer.