Patients with high albumin level were associated with a decreased risk of atrial fibrillation compared with patients with low serum albumin (OR[odds ratio]: 0.62, 95% CI [0.44, 0.89]; <i>I</i> <sup>2</sup> = 76%; <i>P</i> = 0.009). This evidence concerns the gene ALB and atrial fibrillation.