In this case-control study, we investigated the potential associations of rs2609255 (FAM13A), rs2736100 (TERT), rs2076295 (DSP) rs5743890, and rs111521887 (TOLLIP) with IPF, COPD, and CPFE syndrome in a Mexican-mestizo population. The gene discussed is DSP; the disease is chronic obstructive pulmonary disease.