Soluble uPAR levels in patients with idiopathic focal and segmental glomerulosclerosis (FSGS) has attracted a lot of attention after Reiser et al., proposed that soluble uPAR was a prime candidate for the elusive serum permeability factor responsible for recurrent FSGS after kidney transplantations (Wei et al., 2008, 2011). The gene discussed is PLAUR; the disease is focal segmental glomerulosclerosis.