Although the conjugation of ICG to AE105 reduced the affinity for uPAR by 20-fold, initial optical imaging studies on subcutaneous xenotransplants of the U87MG glioblastoma cell line (Allen et al., 2016) led to a specific probe uptake reaching maximal tumor-to-background ratio (TBR) after 6–24 h post iv administration (Juhl et al., 2016). This evidence concerns the gene PLAUR and neoplasm.