PLAU and inflammatory response: In long-term studies, mouse strains that were unable to focus plasminogen activation on their cell surfaces due to wholesale gene ablations (Plaur––/–– or Plau––/––) or gene replacement with an uPAR binding–incompetent uPA-variant (PlauGFDhu/GFDhu)3 all developed chronic hepatic inflammation associated with an impaired fibrin surveillance (Connolly et al., 2010).