PLAUR and paroxysmal nocturnal hemoglobinuria: This particular mode of membrane tethering provides uPAR with several distinct features such as (i) a prevalent clustering within membrane microdomains or membrane rafts (Varma and Mayor, 1998; Caiolfa et al., 2007; Suzuki et al., 2012), (ii) a mechanism for the specific shedding of uPAR via cleavage of the GPI-anchor by GDE3, a glycerophosphodiester phosphodiesterase (van Veen et al., 2017), and (iii) a deficiency of uPAR on bone-marrow derived blood cells from patients with the hematologic disorder paroxysmal nocturnal hemoglobinuria (Ploug et al., 1992b; Hill et al., 2017).