PLAUR and systemic sclerosis: In humans, genetic studies find no association between single missense variants in PLAUR and a robust risk for disease predisposition, except for a few publications where PLAUR variants located outside the protein coding regions were correlated to vascular complications in patients with systemic sclerosis (Manetti et al., 2011) and to a decline in pulmonary function in asthma patients (Barton et al., 2009).