PPARA and early-onset autosomal dominant Alzheimer disease: As shown in Figure 5, among the top 30 enriched pathways (ranked by count), 24 pathways were identical, including Metabolic pathways, PPAR signaling pathway, Alzheimer’s disease, Oxidative phosphorylation, Huntington’s disease, and Focal adhesion in OIM vs. CM group and OIM+DHEA vs. CM group.