Nicotine induces the production of various inflammatory factors, such as interleukin-1β (IL-1β), nuclear factor-κβ, and necrosis factor-α, and NLRP3 inflammasome-mediated pyroptosis was recently considered to be an important pathogenicmechanism on atherosclerosis (Wu et al., 2018). Here, IL1B is linked to atherosclerosis.